Linking the Fields—The Interplay of Organic Synthesis, Biophysical Chemistry, and Cell Biology in the Chemical Biology of Protein Lipidation

ChemBioChem ◽  
2000 ◽  
Vol 1 (3) ◽  
pp. 144-169 ◽  
Author(s):  
Dieter Kadereit ◽  
Jürgen Kuhlmann ◽  
Herbert Waldmann
Keyword(s):  
Organic Synthesis ◽  
Cell Biology ◽  
Chemical Biology ◽  
Protein Lipidation ◽  
Biophysical Chemistry

Lipid Cell Biology: A Focus on Lipids in Cell Division

2018 ◽  
Vol 87 (1) ◽  
pp. 839-869 ◽  
Author(s):  
Elisabeth M. Storck ◽  
Cagakan Özbalci ◽  
Ulrike S. Eggert
Keyword(s):  
Mass Spectrometry ◽  
Cell Division ◽  
Cell Biology ◽  
Chemical Biology ◽  
Structural Integrity ◽  
Advanced Imaging ◽  
Functional Roles ◽  
Lipid Interactions ◽  
Cellular Processes ◽  
Alkyl Side Chains

Cells depend on hugely diverse lipidomes for many functions. The actions and structural integrity of the plasma membrane and most organelles also critically depend on membranes and their lipid components. Despite the biological importance of lipids, our understanding of lipid engagement, especially the roles of lipid hydrophobic alkyl side chains, in key cellular processes is still developing. Emerging research has begun to dissect the importance of lipids in intricate events such as cell division. This review discusses how these structurally diverse biomolecules are spatially and temporally regulated during cell division, with a focus on cytokinesis. We analyze how lipids facilitate changes in cellular morphology during division and how they participate in key signaling events. We identify which cytokinesis proteins are associated with membranes, suggesting lipid interactions. More broadly, we highlight key unaddressed questions in lipid cell biology and techniques, including mass spectrometry, advanced imaging, and chemical biology, which will help us gain insights into the functional roles of lipids.

Chemical biology of protein lipidation: semi-synthesis and structure elucidation of prenylated RabGTPases

2005 ◽  
Vol 3 (7) ◽  
pp. 1157 ◽  
Author(s):  
Anja Watzke ◽  
Luc Brunsveld ◽  
Thomas Durek ◽  
Kirill Alexandrov ◽  
Alexey Rak ◽  
...  
Keyword(s):  
Structure Elucidation ◽  
Chemical Biology ◽  
Protein Lipidation

scholarly journals 1,2,3-Triazoles: Synthesis and Biological Application

2020 ◽  
Author(s):  
Abdul Aziz Ali
Keyword(s):  
Drug Discovery ◽  
Supramolecular Chemistry ◽  
Organic Synthesis ◽  
Chemical Biology ◽  
Materials Science ◽  
Biological Activities ◽  
Fluorescent Imaging ◽  
Polymer Chemistry ◽  
Privileged Structure ◽  
Synthetic Approaches

Among nitrogen-containing heterocyclic compounds, 1,2,3-triazoles are privileged structure motif and received a great deal of attention in academics and industry. Even though absent in nature, 1,2,3-triazoles have found broad applications in drug discovery, organic synthesis, polymer chemistry, supramolecular chemistry, bioconjugation, chemical biology, fluorescent imaging, and materials science. Therefore, the development of facile and straightforward methodology for the synthesis of 1,2,3-triazoles is of noteworthy interest. In this study, emphasis will be given to numerous synthetic approaches for the synthesis of 1,2,3-triazoles, especially the popular click chemistry approach. Furthermore, several biological activities of this promising heterocycle will also be discussed.

ChemInform Abstract: The Use of 3,6-Pyridazinediones in Organic Synthesis and Chemical Biology

ChemInform ◽  
2016 ◽  
Vol 47 (9) ◽  
pp. no-no
Author(s):  
Maximillian T. W. Lee ◽  
Antoine Maruani ◽  
Vijay Chudasama
Keyword(s):  
Organic Synthesis ◽  
Chemical Biology

scholarly journals The allylic chalcogen effect in olefin metathesis

2010 ◽  
Vol 6 ◽  
pp. 1219-1228 ◽  
Author(s):  
Yuya A Lin ◽  
Benjamin G Davis
Keyword(s):  
Natural Products ◽  
Organic Synthesis ◽  
Olefin Metathesis ◽  
Chemical Biology ◽  
Positive Influence ◽  
Efficient Synthesis ◽  
Cross Metathesis ◽  
Allyl Sulfide ◽  
Hydroxy Groups ◽  
Allyl Sulfides

Olefin metathesis has emerged as a powerful tool in organic synthesis. The activating effect of an allylic hydroxy group in metathesis has been known for more than 10 years, and many organic chemists have taken advantage of this positive influence for efficient synthesis of natural products. Recently, the discovery of the rate enhancement by allyl sulfides in aqueous cross-metathesis has allowed the first examples of such a reaction on proteins. This led to a new benchmark in substrate complexity for cross-metathesis and expanded the potential of olefin metathesis for other applications in chemical biology. The enhanced reactivity of allyl sulfide, along with earlier reports of a similar effect by allylic hydroxy groups, suggests that allyl chalcogens generally play an important role in modulating the rate of olefin metathesis. In this review, we discuss the effect of allylic chalcogens in olefin metathesis and highlight its most recent applications in synthetic chemistry and protein modifications.

scholarly journals Now in your DeepDyve store: Nature papers to rent

2011 ◽  
Author(s):  
Martin Fenner
Keyword(s):  
Cell Biology ◽  
Chemical Biology ◽  
Nature Medicine ◽  
Nature Biotechnology

Articles published in Nature, Nature Biotechnology, Nature Cell Biology, Nature Medicine or Nature Chemical Biology are now available for renting from DeepDyve. Downloading or printing is not possible, and the $3.99 rental is for 24 hours.Later this month, ...

scholarly journals First person – Bartika Ghoshal

2021 ◽  
Vol 134 (9) ◽  
Keyword(s):  
Cell Biology ◽  
Chemical Biology ◽  
Extracellular Vesicle ◽  
Indian Institute ◽  
Early Career ◽  
First Person ◽  
Early Career Researchers ◽  
Selection Of

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Bartika Ghoshal is first author on ‘ Non-canonical argonaute loading of extracellular vesicle-derived exogenous single-stranded miRNA in recipient cells’, published in JCS. Bartika is a PhD student in the lab of Dr Suvendra Nath Bhattacharyya at CSIR-Indian Institute of Chemical Biology, Kolkata, India, investigating extracellular vesicle or exosome biology and cell biology.

A List of Highly Influential Journals

2021 ◽  
Vol 11 ◽  
Author(s):  
Editorial Office ROS
Keyword(s):  
Internal Medicine ◽  
Heart Failure ◽  
Molecular Biology ◽  
Cell Biology ◽  
Chemical Biology ◽  
Cell Cancer ◽  
The United States ◽  
Experimental Medicine ◽  
Alphabetical Order ◽  
Cell Cell

This Education & Resources web page provides a list, in alphabetical order, of highly influential journals (typically with an impact factor of 10 or above) where high profile research articles on ROS may be found. This, however, is not intended to be a complete list. LIST IN ALPHABETICAL ORDER American Journal of Gastroenterology American Journal of Human Genetics American Journal of Respiratory and Critical Care Medicine Annals of Internal Medicine Annals of Neurology Autophagy Blood Brain British Medical Journal Cancer Research Cell (and Molecular Cell, Cancer Cell, Cell Metabolism, Cell Stem Cell, Developmental Cell, Cell Host Microbe) Cell Research Chest Circulation Circulation Research Current Biology EMBO J (and EMBO Molecular Medicine) European Heart Journal European Journal of Heart Failure European Respiratory Journal Gastroenterology Genes and Development Genome Biology Genome Research Gut Hepatology Immunity JAMA (and JAMA Internal Medicine, JAMA Cardiology) Journal of Allergy and Clinical Immunology Journal of the American College of Cardiology (and JACC Cardiovascular Imaging, JACC Cardiovascular Interventions, JACC Heart Failure)    Journal of Cell Biology Journal of Clinical Investigation Journal of Experimental Medicine Journal of the American Chemical Society Journal of the National Cancer Institute Lancet (and Lancet Oncology, Lancet Neurology, Lancet Diabetes & Endocrinology) Microbiome Molecular Biology and Evolution Molecular Cancer Molecular Plant Nature (and Nature Genetics, Nature Medicine, Nature Methods, Nature Biotechnology, Nature Materials, Nature Nanotechnology, Nature Communications, Nature Structural & Molecular Biology, Nature Neuroscience, Nature Immunology, Nature Cell Biology, Nature Chemical Biology, Nature Microbiology, Nature Plants, Nature Chemical Biology) Neuron New England Journal of Medicine Nucleic Acids Research Plant Cell PLOS Medicine Proceedings of the National Academy of Sciences of the United States of America Science (and Science Signaling, Science Translational Medicine, Science Immunology)

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